Lowering the GWAS threshold would save millions of dollars

A recent publication (pay-walled) by Boyle et al. introducing the concept of an omnigenic model has generated much discussion. It reminded me of a question I’ve had for a while about the way genetics data is analyzed. Before getting into this, I’ll briefly summarize the general issue. With the completion of the human genome project, human geneticists saw much promise in the possibility of scanning the entire genome for the genes associated with a trait.